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qAll the basic concepts of pharmacokinetics (PKs) are described, with an emphasis on understanding what parameters such as bioavailability, volume of distribution and clearance tell us about the behaviour of a particular drug. The use of PKs in both a drug development and a clinical setting are covered. The essential mathematical basis of PKs is explained, but excessive mathematical complexity is avoided. For all key equations, practical examples of their use are provided. There are plenty of practice questions (along with model answers). Additional spreadsheets are provided on the netq-- provided by publisher.-2 1.5 2 0 5 10 15 20 25 30 Time (h) -1.5 -1 -0.5 0 0.5 1 Figure 6.7 Linearization of the data by plotting the natural log of the concentration versus time. ... Appendix. 2. Derivation of the equation K = Ln(C1/C2) / (T2-T1) Consider the exponential decline in drug concentration ... Ln(C1/C2) / (T2-T1) Download free ebooks at 7 Single intravenous bolus injection into two compartments 7.1 The.

Author: Philip Rowe
Publisher:Bookboon - 2012

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